Magliulo Giuseppe, D'Amico Raffaello, Di Cello Pierfrancesco
Second Department of Otolaryngology, University La Sapienza of Rome, Italy.
J Otolaryngol. 2003 Dec;32(6):400-4. doi: 10.2310/7070.2003.13968.
The object of the present study was to review a series of surgically removed vestibular schwannoma tumours to establish the incidence of delayed facial palsy and to evaluate the course of recovery according to the possible etiology (surgical postoperative edema or viral reactivation) with reference to the time of onset.
The study group was composed of 98 patients with vestibular schwannoma. Sex, age, location, and extent of tumour and postoperative complications were all taken into consideration in the final evaluation. The course of each patient's postoperative facial function was graded according to House and Brackmann's six-grade scale. The incidence and the time of onset of the delayed facial palsy were also evaluated.
The deterioration in the facial function was found to be delayed in 25 of the 98 patients (26%); of these, it occurred in the first 5 days after surgery in 11 cases, between 6 and 13 days in 10 cases, and after 15 days in 14 patients. The incidence rate of the delayed facial dysfunction was not influenced by age, sex, or the size of the tumour. The prognosis of the facial dysfunction was favourable in the majority of cases, and, in fact, there were only five grade III to IV cases 1 year later. Facial dysfunction was over grade III in the majority of the latter five cases, and the period of recovery was long.
Eighty percent of our patients with delayed facial palsy following vestibular schwannoma resection were classified as having excellent or good function. In the remaining patients who had a less favourable recovery, the palsy was more severe, and the onset occurred after some time. This seems to agree with those who are of the opinion that the complication is due to viral reactivation. In these patients, it is advisable to start aggressive medical therapy with antiviral agents such as acyclovir as soon as possible.
本研究的目的是回顾一系列手术切除的前庭神经鞘瘤,确定迟发性面瘫的发生率,并根据可能的病因(手术后脑水肿或病毒再激活),参考发病时间评估恢复过程。
研究组由98例前庭神经鞘瘤患者组成。在最终评估中,考虑了患者的性别、年龄、肿瘤位置和范围以及术后并发症。根据House和Brackmann的六级量表对每位患者术后的面部功能过程进行分级。还评估了迟发性面瘫的发生率和发病时间。
98例患者中有25例(26%)出现面部功能延迟恶化;其中,11例在术后第1个5天内出现,10例在6至13天之间出现,14例在15天后出现。迟发性面部功能障碍的发生率不受年龄、性别或肿瘤大小的影响。大多数情况下,面部功能障碍的预后良好,事实上,1年后只有5例为III至IV级。后5例中的大多数面部功能障碍超过III级,恢复时间较长。
我们的前庭神经鞘瘤切除术后迟发性面瘫患者中,80%的患者面部功能恢复为优或良。在其余恢复较差的患者中,面瘫更严重,且在一段时间后发病。这似乎与认为该并发症是由病毒再激活引起的观点一致。对于这些患者,建议尽早开始使用阿昔洛韦等抗病毒药物进行积极的药物治疗。