α-氯代酮与醛的反应性钡促进的Reformatsky型反应。
Reactive barium-promoted Reformatsky-type reaction of alpha-chloroketones with aldehydes.
作者信息
Yanagisawa Akira, Takahashi Hiroshi, Arai Takayoshi
机构信息
Department of Chemistry, Faculty of Science, Chiba University, Inage, Chiba 263-8522, Japan.
出版信息
Chem Commun (Camb). 2004 Mar 7(5):580-1. doi: 10.1039/b314752p. Epub 2004 Feb 3.
DOI:10.1039/b314752p
PMID:14973617
Abstract
A Reformatsky-type aldol reaction of alpha-chloroketones with aldehydes has been achieved using reactive barium as a low-valent metal in THF; this one-pot process is more effective for obtaining the desired beta-hydroxy ketones in high yields than the stepwise process in which barium enolates are prepared prior to the reaction with aldehydes.
摘要
在四氢呋喃中使用活性钡作为低价金属，实现了α-氯代酮与醛的Reformatsky型羟醛缩合反应；与在与醛反应之前制备钡烯醇盐的分步过程相比，这种一锅法在高产率获得所需的β-羟基酮方面更有效。
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