橙皮苷葡萄糖苷可改善血清胆固醇组成并抑制血管肥大。

Glucosyl hesperidin improves serum cholesterol composition and inhibits hypertrophy in vasculature.

作者信息

Ohtsuki Kazumasa, Abe Asaki, Mitsuzumi Hitoshi, Kondo Masaru, Uemura Kanae, Iwasaki Yumiko, Kondo Yasuhiro

机构信息

Department of Animal Science, Faculty of Agriculture, Okayama University, Okayama 700-8530, Japan.

出版信息

J Nutr Sci Vitaminol (Tokyo). 2003 Dec;49(6):447-50. doi: 10.3177/jnsv.49.447.

DOI:10.3177/jnsv.49.447

PMID:14974738

Abstract

Long-term administration of hesperidin (HES) or glucosyl hesperidin (GHES), a water-soluble analogue of HES, brings about an antihypertensive effect on spontaneously hypertensive rats (SHR). In the present study, we investigated the effects of long-term administration of HES and GHES (corresponding to 30 mg/d/kg body weight) on serum lipid concentration and morphology of vasculature. Serum HDL cholesterol increased in both SHR and Wistar-Kyoto rats (WKY) fed a HES- or GHES-containing diet for 25 wk. Simultaneously, GHES administration reduced the vascular diameter and media-intimal cross-sectional area of the abdominal aorta in SHR. These results suggest that HES as well as GHES improves serum cholesterol composition and that GHES inhibits hypertrophy in vasculature as well.

摘要

长期给予橙皮苷（HES）或其水溶性类似物葡萄糖基橙皮苷（GHES）可对自发性高血压大鼠（SHR）产生降压作用。在本研究中，我们调查了长期给予HES和GHES（相当于30mg/d/kg体重）对血清脂质浓度和血管形态的影响。喂食含HES或GHES饮食25周的SHR和Wistar-Kyoto大鼠（WKY）的血清高密度脂蛋白胆固醇均升高。同时，给予GHES可减小SHR腹主动脉的血管直径和中膜-内膜横截面积。这些结果表明，HES和GHES均可改善血清胆固醇组成，且GHES还可抑制血管肥大。