Simsek Baris, Karacaer Ozgül, Karaca Inci
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Gazi, Emek, Ankara, Turkey.
Chin Med J (Engl). 2004 Feb;117(2):291-5.
The purpose of this study is to review the urine products of bone breakdown as markers of bone resorption and usefulness of urinary hydroxyproline.
Related researches published in 1985 - 2000 were systematically reviewed.
Bone markers could be used for early diagnosis of bone metabolic diseases. Biochemical markers of bone resorption that reflect osteoclast activity and/or collagen degradation provide a new and potentially important clinical tool for the assessment and monitoring of bone metabolism. Assessment of bone resorption can be achieved with measurement of urinary hydroxylysine glycosides, urinary excretion of the collagen pyridinium cross-links, urinary excretion of type I collagen telopeptide breakdown products (cross-linked telopeptides) and urinary hydroxyproline.
Urinary hydroxyproline has been in use as a marker of bone resorption, but it lacks sensitivity and specificity. It is a modified amino acid that is a metabolic product of collagen breakdown. Hydroxyproline may be released either free or with fragments of the collagen molecule attached during bone resorption, and it is also liberated by the breakdown of complement and nonskeletal collagen.
本研究旨在回顾作为骨吸收标志物的骨分解尿液产物以及尿羟脯氨酸的用途。
对1985年至2000年发表的相关研究进行系统回顾。
骨标志物可用于骨代谢疾病的早期诊断。反映破骨细胞活性和/或胶原蛋白降解的骨吸收生化标志物为评估和监测骨代谢提供了一种新的且可能重要的临床工具。通过测量尿羟赖氨酸糖苷、胶原蛋白吡啶交联物的尿排泄量、I型胶原末端肽降解产物（交联末端肽）的尿排泄量和尿羟脯氨酸可实现对骨吸收的评估。
尿羟脯氨酸一直被用作骨吸收的标志物，但它缺乏敏感性和特异性。它是一种修饰氨基酸，是胶原蛋白分解的代谢产物。在骨吸收过程中，羟脯氨酸可能以游离形式释放，也可能与附着的胶原蛋白分子片段一起释放，并且它也可通过补体和非骨骼胶原蛋白的分解而释放。
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