Willett Kristine L, Roth Robert A, Walker Larry
Department of Pharmacology and Environmental Toxicology, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA.
Toxicol Sci. 2004 May;79(1):4-9. doi: 10.1093/toxsci/kfh075. Epub 2004 Feb 19.
Botanical dietary supplements (herbal products) have flooded the market in the United States over the past decade, and studies show a significant percentage of Americans use them. With increasing frequency and duration of exposure, some serious adverse effects, though relatively uncommon, have been reported. Among the most troublesome is the association of some botanicals with serious hepatotoxicity. In some cases, hepatotoxicity has been linked to the consumption of botanicals with recognized hepatotoxic components (e.g., pyrrolizidine alkaloids). However, in other cases, the causative agent(s) is less clear and, overall, the mechanisms of hepatotoxicity are poorly understood. To help create a scientific basis for understanding botanical-induced hepatotoxicity and better tools for hepatotoxicity assessment and prediction, the National Center for Natural Product Research (NCNPR) hosted a workshop (September 8 and 9, 2003) in cooperation with the Center for Food Safety and Applied Nutrition (CFSAN) of the Food and Drug Administration (FDA). The workshop featured presentations by 22 experts and was attended by 65 individuals. The agenda can be found in the supplementary data at www.toxsci.oupjournals.org.
在过去十年中，植物性膳食补充剂（草药产品）在美国市场泛滥，研究表明相当一部分美国人在使用它们。随着接触频率和时长的增加，一些严重的不良反应虽相对不常见，但已有报告。其中最麻烦的是一些植物与严重肝毒性之间的关联。在某些情况下，肝毒性与含有公认肝毒性成分的植物（如吡咯里西啶生物碱）的食用有关。然而，在其他情况下，致病因素不太明确，总体而言，肝毒性的机制了解甚少。为了为理解植物性肝毒性建立科学基础，并为肝毒性评估和预测提供更好的工具，国家天然产物研究中心（NCNPR）与美国食品药品监督管理局（FDA）的食品安全与应用营养中心（CFSAN）合作举办了一次研讨会（2003年9月8日和9日）。该研讨会有22位专家进行了演讲，65人参加。议程可在www.toxsci.oupjournals.org的补充数据中找到。
