用低分子量化合物抑制p53与hdm2的相互作用。

Inhibition of the p53-hdm2 interaction with low molecular weight compounds.

作者信息

Chène Patrick

机构信息

Novartis, Oncology, Department, Basel, Switzerland.

出版信息

Cell Cycle. 2004 Apr;3(4):460-1. doi: 10.4161/cc.3.4.791. Epub 2004 Apr 1.

DOI:10.4161/cc.3.4.791

PMID:14976429

Abstract

The hdm2 protein, upon binding to p53, inhibits its tumor suppressor activity. The inhibition of the p53-hdm2 interaction represents therefore a new therapeutic strategy to activate wild type p53 in tumors. Potent low molecular weight compounds inhibiting this protein-protein interaction, which are active in vivo, have just been identified. This offers new perspectives and hopes in this research area.

摘要

HDM2蛋白与p53结合后，会抑制其肿瘤抑制活性。因此，抑制p53与HDM2的相互作用代表了一种在肿瘤中激活野生型p53的新治疗策略。刚刚鉴定出了在体内具有活性的、能抑制这种蛋白质-蛋白质相互作用的强效低分子量化合物。这为该研究领域提供了新的前景和希望。