Danil'chenko D I, Koenig F, Riedl K, Schnorr D, Waldman A, Al-Shukri S, Loening S A
Vopr Onkol. 2003;49(6):734-7.
Macroscopic fluorescence which is induced with aminolevulinic acid (ALA) allows visualizing of small flat tumors, carcinoma in situ, true neoplasm margins and dysplasias of the bladder. Following ALA instillation, cystoscopy was performed under both standard and blue light illumination. In a prospective randomized multicenter study, 102 patients underwent TUR of bladder tumor(s) either with white light or ALA-fluorescence. Significant reduction in the number of residual tumours was detected in 59% (p = 0.005) after 8 weeks, 3 months--in 58% (p = 0.002) and 6 months in 38% (p = 0.01) respectively.
由氨基乙酰丙酸（ALA）诱导产生的宏观荧光可使膀胱内的小扁平肿瘤、原位癌、真正的肿瘤边缘以及发育异常清晰可见。在膀胱内灌注ALA后，分别在标准光和蓝光照明下进行膀胱镜检查。在一项前瞻性随机多中心研究中，102例患者接受了白光或ALA荧光膀胱肿瘤经尿道切除术。8周后，59%的患者残余肿瘤数量显著减少（p = 0.005）；3个月时，58%的患者出现显著减少（p = 0.002）；6个月时，38%的患者出现显著减少（p = 0.01）。
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