Milton I D, Vlasak R, Nowotny N, Rodak L, Carter M J
Division of Virology, School of Pathological Sciences, The Medical School, Newcastle upon Tyne, UK.
FEMS Microbiol Lett. 1992 May 15;72(1):37-42. doi: 10.1016/0378-1097(92)90486-8.
Comparison of sequence data is necessary in older to investigate virus origins, identify features common to virulent strains, and characterize genomic organization within virus families. A virulent caliciviral disease of rabbits recently emerged in China. We have sequenced 1100 bases from the 3' ends of two independent European isolates of this virus, and compared these with previously determined calicivirus sequences. Rabbit caliciviruses were closely related, despite the different countries in which isolation was made. This supports the rapid spread of a new virus across Europe. The capsid protein sequences of these rabbit viruses differ markedly from those determined for feline calicivirus, but a hypothetical 3' open reading frame is relatively well conserved between the caliciviruses of these two different hosts and argues for a functional role.
为了研究病毒起源、确定毒株共有的特征以及描绘病毒家族内的基因组结构，有必要对序列数据进行比较。一种兔的烈性杯状病毒病最近在中国出现。我们对该病毒两个独立的欧洲分离株的3'端进行了1100个碱基的测序，并将这些序列与先前测定的杯状病毒序列进行了比较。尽管分离地点不同，但兔杯状病毒密切相关。这支持了一种新病毒在欧洲的快速传播。这些兔病毒的衣壳蛋白序列与猫杯状病毒的序列明显不同，但在这两种不同宿主的杯状病毒之间，一个假定的3'开放阅读框相对保守，这表明它具有功能作用。
