Greco Steven J, Corcoran Kelly E, Cho Kyung Jin, Rameshwar Pranela
Graduate School of Biomedical Sciences, Interdisciplinary Program, UMDNJ, Newark, NJ 07103, USA.
Front Biosci. 2004 May 1;9:1782-93. doi: 10.2741/1373.
The mammalian tachykinins mediate crosstalk within the neural-immune-hematopoietic axis. Hematopoiesis occurs in the adult bone marrow (BM) and it is described as the method by which the immune system is replenished by a finite number of hematopoietic stem cells (HSC). These cells are found in the BM close to the endosteum where the oxygen level is the lowest. The BM is also resident to mesenchymal stem cell (MSC). The functions of HSC depend on the MSC to generate the supporting stromal cells. This review discusses possible mechanisms by which the MSC act as the 'gatekeeper' in the BM and regulate immune cells in and out of the BM. The roles of the tachykinins are discussed in the context of homeostasis in the BM and as mediators of BM disruption. The involvement of the tachykinins within the BM microenvironment and the development of immune cells in the BM are explained.
哺乳动物速激肽介导神经 - 免疫 - 造血轴内的串扰。造血作用发生在成年骨髓（BM）中，它被描述为免疫系统由有限数量的造血干细胞（HSC）补充的方式。这些细胞存在于骨髓中靠近内膜的位置，那里的氧水平最低。骨髓也是间充质干细胞（MSC）的驻留部位。造血干细胞的功能依赖于间充质干细胞来生成支持性基质细胞。本综述讨论了间充质干细胞作为骨髓中“守门人”并调节进出骨髓的免疫细胞的可能机制。在骨髓内稳态的背景下以及作为骨髓破坏的介质，讨论了速激肽的作用。解释了速激肽在骨髓微环境中的参与以及骨髓中免疫细胞的发育。
