Barreiro Olga, Vicente-Manzanares Miguel, Urzainqui Ana, Yáñez-Mó Maria, Sánchez-Madrid Francisco
Servicio de Inmunologia, Hospital de la Princesa, Universidad Autónoma de Madrid, 28006 Madrid, Spain.
Front Biosci. 2004 May 1;9:1849-63. doi: 10.2741/1285.
Leukocyte transendothelial migration during homing and inflammation requires drastic cell morphological changes, involving cytoskeletal-directed clustering of adhesion receptors in specialized protrusive membrane structures in leukocytes and endothelial cells. Extravasation is an active process not only for leukocytes but also for endothelial cells, which promote the rapid and efficient entry of leukocytes to the target tissues, without disturbing the integrity of the endothelial barrier. Herein, we have revised the specialized protrusive structures (microvilli, endothelial docking structures, leukocyte lamellipodia and uropod) involved in the different stages of leukocyte extravasation. The adhesion receptor redistribution, cytoskeletal remodelling and intracellular signaling events that participate in this phenomenon are also discussed.
归巢和炎症过程中的白细胞跨内皮迁移需要细胞形态发生剧烈变化，这涉及白细胞和内皮细胞中粘附受体在特殊突出膜结构中的细胞骨架导向聚集。外渗不仅对白细胞是一个活跃过程，对内皮细胞也是如此，内皮细胞促进白细胞快速有效地进入靶组织，同时不破坏内皮屏障的完整性。在此，我们修订了参与白细胞外渗不同阶段的特殊突出结构（微绒毛、内皮对接结构、白细胞片状伪足和尾足）。还讨论了参与这一现象的粘附受体重新分布、细胞骨架重塑和细胞内信号事件。
