α1抗胰蛋白酶与哮喘的患病率及严重程度
Alpha1 antitrypsin and the prevalence and severity of asthma.
作者信息
von Ehrenstein O S, Maier E M, Weiland S K, Carr D, Hirsch T, Nicolai T, Roscher A A, von Mutius E
机构信息
University Children's Hospital, Munich, Germany.
出版信息
Arch Dis Child. 2004 Mar;89(3):230-1. doi: 10.1136/adc.2002.023614.
Abstract
In a random sample of children (aged 9-11 years; n = 5629), who were studied according to the ISAAC phase II protocol, heterozygosity of the alpha1 antitrypsin (alpha1-AT) Pi genotypes MS or MZ, or low alpha1-AT plasma levels, were not associated with an increased risk of developing asthma. Asthmatics with low levels of alpha1-AT were particularly prone to develop airway hyperresponsiveness and reduced lung function.
摘要
在一项按照国际儿童哮喘和变应性疾病研究（ISAAC）第二阶段方案进行研究的儿童随机样本（9至11岁；n = 5629）中，α1抗胰蛋白酶（α1-AT）Pi基因型MS或MZ的杂合性，或α1-AT血浆水平较低，与患哮喘风险增加无关。α1-AT水平较低的哮喘患者尤其容易出现气道高反应性和肺功能下降。
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