Bechetoille A, Chabanais J L, Jallet G, Saraux H
J Fr Ophtalmol. 1978 Feb;1(2):139-43.
An experimental study, by angiography of the anterior segment of rabbit's eye, estimates the permeability of the hemato-aqueous barrier, using fluorescein. A trauma of the eye (contusion) leads to a rapid and significant increase in this permeability. However, local pretreatment, using an ophthalmic solution of 0,33% indometacine, almost completely stabilizes the hemato-aqueous barrier, even for elements as diffusible as fluorescein. These results suggest that application of a similar preparation to the human eye could be useful in the treatment of ocular contusions, chemical burns and angle-closure glaucoma. But the best perspective could be the application of the indometacine solution to the eye, before an operation, to reduce the sideeffects of surgery relative to the surgical break of the hemato-aqueous barrier.
一项实验研究通过对兔眼前段进行血管造影，使用荧光素估计血-房水屏障的通透性。眼部创伤（挫伤）会导致这种通透性迅速且显著增加。然而，使用0.33%吲哚美辛眼药水进行局部预处理，即使对于像荧光素这样易扩散的物质，也几乎能完全稳定血-房水屏障。这些结果表明，将类似制剂应用于人类眼睛可能对治疗眼部挫伤、化学烧伤和闭角型青光眼有用。但最佳前景可能是在手术前将吲哚美辛溶液应用于眼睛，以减少因手术破坏血-房水屏障而产生的手术副作用。
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