生理盐水湿润米索前列醇与干燥米索前列醇用于孕早期妊娠失败的随机试验。
A randomized trial of saline solution-moistened misoprostol versus dry misoprostol for first-trimester pregnancy failure.
作者信息
Gilles Jerry M, Creinin Mitchell D, Barnhart Kurt, Westhoff Carolyn, Frederick Margaret M, Zhang Jun
机构信息
University of Miami, Miami, FL, USA.
出版信息
Am J Obstet Gynecol. 2004 Feb;190(2):389-94. doi: 10.1016/j.ajog.2003.08.024.
OBJECTIVE
The purpose of this study was to estimate whether the efficacy of treatment with intravaginal misoprostol for first-trimester pregnancy failure is enhanced by the addition of saline solution.
STUDY DESIGN
Eighty women with embryonic/fetal death or anembryonic pregnancy were assigned randomly to receive either 800 microg of misoprostol with saline solution (group I, 41 women) or without (group II, 39 women). Treatment was repeated on day 3 if the gestational sac remained. Curettage was performed if the gestational sac remained on day 8 or as necessary during at least 30 days of follow-up. Data were analyzed with the Student t test and the chi(2) or Fisher exact test.
RESULTS
By the first follow-up visit, 73% (group I) and 64% (group II) of women passed the gestational sac (P=.38). By the second follow-up visit, expulsion rates were 83% and 87%, respectively (P=.59). Five subjects in each group underwent curettage.
CONCLUSION
Misoprostol is effective for the treatment of failed first-trimester pregnancy. The expulsion rate is not improved by adding saline solution.
目的
本研究旨在评估添加生理盐水是否能提高米索前列醇阴道给药治疗早期妊娠失败的疗效。
研究设计
80例胚胎/胎儿死亡或空孕囊妊娠的女性被随机分为两组，一组41例接受800微克米索前列醇加生理盐水治疗（I组），另一组39例接受800微克米索前列醇但不加生理盐水治疗（II组）。若孕囊仍存在，则在第3天重复治疗。若孕囊在第8天仍存在或在至少30天的随访期间有必要，则进行刮宫术。数据采用Student t检验和卡方检验或Fisher精确检验进行分析。
结果
首次随访时，I组73%、II组64%的女性排出了孕囊（P = 0.38）。第二次随访时，排出率分别为83%和87%（P = 0.59）。每组各有5名受试者接受了刮宫术。
结论
米索前列醇对治疗早期妊娠失败有效。添加生理盐水并未提高排出率。
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