未经治疗的格雷夫斯眼病患者血清白细胞介素-18水平并未升高。

Serum IL-18 levels are not increased in patients with untreated Graves' ophthalmopathy.

作者信息

Wakelkamp I M M J, Prummel M F, Wiersinga W M

机构信息

Department of Endocrinology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

出版信息

Horm Metab Res. 2004 Jan;36(1):44-7. doi: 10.1055/s-2004-814102.

DOI:10.1055/s-2004-814102

PMID:14983406

Abstract

OBJECTIVE

Cytokines play an important role in autoimmune thyroid diseases, and serum levels may reflect the activity of the immune process. This is particularly interesting in Graves' ophthalmopathy, where a reliable serum activity marker is warranted. Interleukin-18 (IL-18) is a potent Th1 cytokine, known to induce interferon (IFN)-gamma and the aim of this study was to evaluate serum IL-18 levels in Graves' ophthalmopathy.

METHODS

Serum IL-18 was measured by ELISA in 52 patients with untreated Graves' ophthalmopathy (who all had been rendered euthyroid with antithyroid drugs), 52 healthy controls matched for sex, age, and smoking habits, and 15 euthyroid patients who had been treated for Graves' hyperthyroidism and ophthalmopathy in the past.

RESULTS

Serum IL-18 (median values in pg/ml with range) levels did not differ between the untreated Graves' ophthalmopathy patients-226 (61-704) pg/ml, matched healthy controls-194 (17-802) pg/ml, and Graves' ophthalmopathy patients treated in the past-146 (0-608) pg/ml. No correlation was observed between serum IL-18 levels and thyroid function or antithyroid antibodies. There was no correlation between serum IL-18 levels and smoking habits.

CONCLUSION

We conclude that Graves' ophthalmopathy does not affect serum IL-18.

摘要

目的

细胞因子在自身免疫性甲状腺疾病中起重要作用，血清水平可能反映免疫过程的活性。这在格雷夫斯眼病中尤为有趣，因为需要一种可靠的血清活性标志物。白细胞介素-18（IL-18）是一种强效的Th1细胞因子，已知可诱导干扰素（IFN）-γ，本研究的目的是评估格雷夫斯眼病患者的血清IL-18水平。

方法

采用酶联免疫吸附测定法（ELISA）检测52例未经治疗的格雷夫斯眼病患者（均用抗甲状腺药物使甲状腺功能正常）、52例性别、年龄和吸烟习惯相匹配的健康对照者以及15例既往曾接受格雷夫斯甲亢和眼病治疗的甲状腺功能正常患者的血清IL-18水平。

结果

未经治疗的格雷夫斯眼病患者血清IL-18水平[中位数（pg/ml）及范围]为226（61-704）pg/ml，匹配的健康对照者为194（17-802）pg/ml，既往接受治疗的格雷夫斯眼病患者为146（0-608）pg/ml，三者之间无差异。血清IL-18水平与甲状腺功能或抗甲状腺抗体之间未观察到相关性。血清IL-18水平与吸烟习惯之间也无相关性。