Mikami Yoshiki, Maehata Kenichirou, Fujiwara Keiichi, Sasano Hironobu
Department of Pathology, Tohoku University Graduate School of Medical Science, 2-1 Seiryo-machi, Aoba-ward, Sendai, Miyagi 980-8575, Japan.
Gynecol Oncol. 2004 Mar;92(3):974-7. doi: 10.1016/j.ygyno.2003.11.021.
There have been many cases of multiple malignant neoplasms involving the female genital tract reported, but involvement by epithelial and hematologic malignancy is extremely rare.
A 52-year-old woman, who was followed for stage 0 chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), had developed invasive squamous cell carcinoma of the uterine cervix. Microscopic examination of the hysterectomy specimen disclosed invasive squamous cell carcinoma in the cervix and monotonous populations of small lymphoid cells with proliferation centers, which are consistent with CLL/SLL, in the cervix as well as parametrium. Thirty months after the initial diagnosis of CLL/SLL, the patient died with systemic dissemination of squamous cell carcinoma, but the CLL/SLL remained a local disease.
The clinical course of squamous cell carcinoma in this case appeared to be aggressive, but it was unclear whether the outcome was associated with an altered immune status due to the presence of concurrent CLL/SLL.
已有许多关于女性生殖道发生多种恶性肿瘤的病例报道，但上皮性和血液学恶性肿瘤同时累及的情况极为罕见。
一名52岁女性，因0期慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL/SLL）接受随访，之后发生了子宫颈浸润性鳞状细胞癌。对子宫切除标本进行显微镜检查发现，宫颈存在浸润性鳞状细胞癌，宫颈及宫旁组织中有小淋巴细胞的单一群体并伴有增殖中心，这与CLL/SLL相符。在最初诊断为CLL/SLL 30个月后，患者因鳞状细胞癌全身播散而死亡，但CLL/SLL仍局限于局部。
该病例中鳞状细胞癌的临床病程似乎具有侵袭性，但尚不清楚其预后是否与同时存在的CLL/SLL导致的免疫状态改变有关。
Zotero 插件