Louzir Bassem, Ben Abdelhafidh Nadia, Bahri Meriem, M'Sadek Fehmi, Ksontini Imen, Boussema Ezzeddine, Othmani Salah
Service de Médecine Interne, Hôpital Militaire Principal d'Instruction de Tunis, Montfleury, Tunis.
Tunis Med. 2003 Dec;81(12):963-6.
The association of myasthenia gravis (MG) and systemic lupus erythematosus (SLE) is a quite rare one. We report here one case and try to discuss the physiopathologic mechanisms and also the clinical, evolutive and therapeutic features of this morbid association. It's the case of a woman of 43 years old followed in our department since 1999. The patient has been treated by corticosteroids (prednisone) with monthly administered cyclophospamide pulses. Nine months lately, she develops a diplopia with a ptosis, a dysphagia and a muscular weakness. The treatment was mainly based on intravenous immunoglobulins. The later evolution was favourable. The coexistence of SLE and MG is not casual. It must be considered in every lupic patient developing neuromuscular troubles.
重症肌无力（MG）与系统性红斑狼疮（SLE）的关联相当罕见。我们在此报告一例，并试图探讨这种疾病关联的病理生理机制以及临床、演变和治疗特征。这是一名43岁女性的病例，自1999年起在我们科室接受治疗。该患者曾接受皮质类固醇（泼尼松）治疗，并每月给予环磷酰胺脉冲治疗。九个月后，她出现复视伴上睑下垂、吞咽困难和肌肉无力。治疗主要基于静脉注射免疫球蛋白。后来的病情演变是有利的。SLE和MG的共存并非偶然。在每一位出现神经肌肉问题的狼疮患者中都必须考虑到这一点。
