[凝血系统相关基因的突变与异常表达及高凝状态]

[Mutation and unusual expression of clotting system-related genes and hypercoagulability].

作者信息

Zhao Yu-Hua, Liu Bing-Wen

机构信息

Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041.

出版信息

Sheng Li Ke Xue Jin Zhan. 2003 Oct;34(4):324-8.

PMID:14992014

Abstract

Hypercoagulability is a risk factor for atherosclerosis (As) and plays an important role in the development of As. Hypercoagulability results from mutation and unusual expression of clotting system-related genes, anticlotting system-related genes, fibrinolytic system-related genes and other related genes. Factor V gene, prothrombin gene and tissue factor gene in clotting system, thrombomodulin gene and antithrombin III in anticlotting system, plasminogen activator inhibitor-1 gene in fibrinolytic system, are related with hypercoagulability tightly.

摘要

高凝状态是动脉粥样硬化（As）的一个危险因素，在As的发生发展中起重要作用。高凝状态是由凝血系统相关基因、抗凝系统相关基因、纤溶系统相关基因及其他相关基因的突变和异常表达所致。凝血系统中的因子V基因、凝血酶原基因和组织因子基因，抗凝系统中的血栓调节蛋白基因和抗凝血酶III，纤溶系统中的纤溶酶原激活物抑制剂-1基因，均与高凝状态密切相关。