Roopra A, Huang Y, Dingledine R
Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA.
Mol Interv. 2001 Oct;1(4):219-28.
Neurons regulate the expression of genes essential to individual neuron function through elegant combinatorial interactions among a limited number of transcription factors. In addition, an economy of regulatory control is practiced within the nucleus that belies conceptual divisions of transcription factors into "repressors" and "activators." Studies of the neural restrictive silencer element (NRSE, also known as RE1) and its repressor protein have revealed a multitude of mechanisms by which transcriptional regulation is not only elaborated in normal neuronal development, but perverted in disease states.
神经元通过有限数量的转录因子之间精妙的组合相互作用来调控对单个神经元功能至关重要的基因的表达。此外，细胞核内实行一种调控控制的经济性，这与将转录因子概念性地分为“阻遏物”和“激活物”的分类相悖。对神经限制性沉默元件（NRSE，也称为RE1）及其阻遏蛋白的研究揭示了多种机制，通过这些机制，转录调控不仅在正常神经元发育过程中得以精细调节，而且在疾病状态下会发生畸变。
