抗甲状腺药物与甲状腺激素合成的仿生学研究

Biomimetic studies on anti-thyroid drugs and thyroid hormone synthesis.

作者信息

Roy Gouriprasanna, Nethaji Munirathinam, Mugesh G

机构信息

Department of Inorganic & Physical Chemistry, Indian Institute of Science, Bangalore 560 012, India.

出版信息

J Am Chem Soc. 2004 Mar 10;126(9):2712-3. doi: 10.1021/ja039860g.

DOI:10.1021/ja039860g

PMID:14995183

Abstract

The selenium analogues of anti-thyroid drugs exhibit their anti-thyroid action by a mechanism different from that of MMI. The selenium analogue of MMI and related selenium compounds exhibit high GPx activity, providing a novel method for the reversible inhibition of thyroid hormone biosynthesis.

摘要

抗甲状腺药物的硒类似物通过一种不同于甲巯咪唑（MMI）的机制发挥其抗甲状腺作用。MMI的硒类似物及相关硒化合物具有高谷胱甘肽过氧化物酶（GPx）活性，为可逆抑制甲状腺激素生物合成提供了一种新方法。