环腺苷酸受体蛋白同源物的缺失会降低天蓝色链霉菌的萌发率并影响其形态发育。
Deletion of a cyclic AMP receptor protein homologue diminishes germination and affects morphological development of Streptomyces coelicolor.
作者信息
Derouaux A, Halici S, Nothaft H, Neutelings T, Moutzourelis G, Dusart J, Titgemeyer F, Rigali S
机构信息
Centre d'Ingénierie des Protéines, Université de Liège, Institut de Chimie B6, B-4000 Liège, Belgium.
出版信息
J Bacteriol. 2004 Mar;186(6):1893-7. doi: 10.1128/JB.186.6.1893-1897.2004.
Abstract
Open reading frame SCO3571 of Streptomyces coelicolor encodes a protein of the cyclic AMP (cAMP) receptor protein (CRP) superfamily of regulatory proteins. A mutant revealed a dramatic defect in germination, followed by growth delay and earlier sporulation. This phenotype correlates with those of an adenylate cyclase (cya) mutant that cannot synthesize cAMP. This finding suggests that S. coelicolor may use a Cya-cAMP-CRP system to trigger complex physiological processes such as morphogenesis.
摘要
天蓝色链霉菌的开放阅读框SCO3571编码一种属于调节蛋白环磷酸腺苷（cAMP）受体蛋白（CRP）超家族的蛋白质。一个突变体显示出在萌发时存在严重缺陷，随后生长延迟且孢子形成提前。这种表型与不能合成cAMP的腺苷酸环化酶（cya）突变体的表型相关。这一发现表明，天蓝色链霉菌可能利用Cya-cAMP-CRP系统来触发诸如形态发生等复杂的生理过程。
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