对临床完全缓解的卵巢癌患者进行腹腔内顺铂化疗。

Intraperitoneal cisplatin chemotherapy in ovarian carcinoma patients who are clinically in complete remission.

作者信息

Menczer J, Ben-Baruch G, Rizel S, Brenner H

机构信息

Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.

出版信息

Gynecol Oncol. 1992 Aug;46(2):222-5. doi: 10.1016/0090-8258(92)90259-l.

DOI:10.1016/0090-8258(92)90259-l

PMID:1500025

Abstract

Three courses of intraperitoneal cisplatin chemotherapy with systemic thiosulfate protection were administered to 31 stage II-IV ovarian carcinoma patients who were clinically in complete remission after completion of postoperative cisplatin-based combination chemotherapy. The 5-year survival rate was 60.4% and the median progression-free interval 35 months. Among 25 patients who underwent second-look laparotomy, the survival and the duration of the progression-free interval were significantly better in those with a pathologically confirmed complete response. Short-term intraperitoneal cisplatin chemotherapy should be considered for consolidation of treatment in ovarian carcinoma patients who are clinically in complete remission.

摘要

对31例II-IV期卵巢癌患者进行了三个疗程的腹腔内顺铂化疗，并给予全身硫代硫酸盐保护，这些患者在术后以顺铂为基础的联合化疗完成后临床上处于完全缓解状态。5年生存率为60.4%，无进展生存期的中位数为35个月。在25例行二次剖腹探查的患者中，病理证实完全缓解的患者生存率和无进展生存期明显更好。对于临床上处于完全缓解状态的卵巢癌患者，应考虑进行短期腹腔内顺铂化疗以巩固治疗。