不同年龄大鼠突触体中脱氢表雄酮谷氨酸释放的影响。

Effect of DHEA glutamate release from synaptosomes of rats at different ages.

作者信息

Lhullier Francisco L R, Riera Neusa G, Nicolaidis Rafael, Junqueira Débora, Dahm Kelly C S, Cipriani Franciele, Brusque Ana M, Souza Diogo O

机构信息

Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

出版信息

Neurochem Res. 2004 Feb;29(2):335-9. doi: 10.1023/b:nere.0000013735.50736.0a.

DOI:10.1023/b:nere.0000013735.50736.0a

PMID:15002728

Abstract

Dehydroepiandrosterone (DHEA) exerts multiple effects in the central nervous system. Most of them seem to be mediated through their nongenomic actions on neurotransmitter receptors, and these actions occur within seconds or milliseconds. DHEA increases neuronal excitability, enhances neuronal plasticity, and has neuroprotective properties. By investigating glutamate release from synaptosomes of rats at different ages (from 17 days to 12 months), we observed that (i) there is an increase in basal and K(+)-stimulated L-[3H] glutamate release in rats at 12 months old, when compared to other ages; and (ii) there is an inhibitory effect of DHEA on basal L-[3H] glutamate release in 12 months old. This inhibitory effect of DHEA could be related to its reported protective role against excitotoxicity caused by overstimulation of the glutamatergic system and ageing.

摘要

脱氢表雄酮（DHEA）在中枢神经系统中发挥多种作用。其中大多数作用似乎是通过其对神经递质受体的非基因组作用介导的，这些作用在数秒或数毫秒内发生。DHEA可增加神经元兴奋性、增强神经元可塑性并具有神经保护特性。通过研究不同年龄（17天至12个月）大鼠突触体中谷氨酸的释放，我们观察到：（i）与其他年龄相比，12个月大的大鼠基础和K⁺刺激的L-[³H]谷氨酸释放增加；（ii）DHEA对12个月大的大鼠基础L-[³H]谷氨酸释放有抑制作用。DHEA的这种抑制作用可能与其报道的对谷氨酸能系统过度刺激和衰老引起的兴奋性毒性的保护作用有关。