Pasieka Z, Kuzdak K, Czyz W, Stepień H, Komorowski J
Clinic of General and Endocrinological Surgery; Institute of Endocrinology, Medical University of Lodz, Lodz, 93-513 Poland.
Neoplasma. 2004;51(1):34-7.
The growth of a neoplasm and its ability to form metastases is a multistep process dependent on angiogenesis and immunological reactions of the organism. In this process adhesive factors are also involved. The aim of this work was estimation of the concentration of soluble intercellular adhesion molecules (sICAM-1) and vascular cellular adhesion molecules (sVCAM-1) in the serum of peripheral blood of patients with thyroid cancer before operation. The study comprised 48 patients ( 38 women and 10 men) aged from 18 to 87 years, in whom thin needle aspiration biopsy revealed cancer of the thyroid. Postoperative histopathological examination showed papillary cancer in 35 patients, oxyphilic cancer in 5 patients, anaplastic cancer in 4 and medullary cancer in 4 patients. In those patients, using the immunoenzymatic method ELISA, the concentration of sICAM-1 and sVCAM-1 in the serum of peripheral blood was determined. The control group comprised 26 healthy persons. We found statistically significant increase of sICAM-1 concentration in serum in all forms of cancer, in comparison with the control group. Mean concentrations of sICAM-1 were as follows: in papillary cancer patients 455.23+/-28.66 vs. 299.62+/-11.54 ng/ml, p<0.05; in oxyphilic cancer 455.60+/-95.21 vs. 299.62+/-11.54 ng/ml, p<0.05; in anaplastic cancer 570.00+/-170.89 vs. 299.62+/-11.54 ng/ml, p<0.05; and in medullary cancer 512.00+/-11.46 vs. 299.62+/-11.54 ng/ml, p<0.05. The mean concentration of sVCAM-1 in serum was statistically significantly higher than in the control group only in case of anaplastic cancer (1033.75+/-86.30 vs. 644.58+/-27.30 ng/ml; p<0.05). We evaluated the correlation coefficient between the concentration of sICAM-1 and sVCAM-1 in the serum of patients with thyroid cancer. Positive correlation was observed between the concentration of sICAM-1 and sVCAM-1. The obtained results confirm essential role of the investigated adhesive factors in the process of thyroid cancer growth.
肿瘤的生长及其形成转移的能力是一个多步骤过程，依赖于血管生成和机体的免疫反应。在这个过程中，黏附因子也参与其中。本研究的目的是评估甲状腺癌患者术前外周血血清中可溶性细胞间黏附分子（sICAM-1）和血管细胞黏附分子（sVCAM-1）的浓度。该研究纳入了48例患者（38名女性和10名男性），年龄在18至87岁之间，细针穿刺活检显示为甲状腺癌。术后组织病理学检查显示，35例为乳头状癌，5例为嗜酸性癌，4例为未分化癌，4例为髓样癌。对这些患者采用免疫酶联法（ELISA）测定外周血血清中sICAM-1和sVCAM-1的浓度。对照组包括26名健康人。我们发现，与对照组相比，所有癌症类型患者血清中sICAM-1浓度均有统计学意义的升高。sICAM-1的平均浓度如下：乳头状癌患者为455.23±28.66 ng/ml，而对照组为299.62±11.54 ng/ml，p<0.05；嗜酸性癌为455.60±95.21 ng/ml，对照组为299.62±11.54 ng/ml，p<0.05；未分化癌为570.00±170.89 ng/ml，对照组为299.62±11.54 ng/ml，p<0.05；髓样癌为512.00±11.46 ng/ml，对照组为299.62±11.54 ng/ml，p<0.05。血清中sVCAM-1的平均浓度仅在未分化癌患者中显著高于对照组（1033.75±86.30 ng/ml对644.58±27.30 ng/ml；p<0.05）。我们评估了甲状腺癌患者血清中sICAM-1和sVCAM-1浓度之间的相关系数。观察到sICAM-1和sVCAM-1浓度之间呈正相关。所得结果证实了所研究的黏附因子在甲状腺癌生长过程中的重要作用。
Zotero 插件