Berteau Olivier, Stenutz Roland
Department of Chemistry, Swedish University of Agricultural Sciences, PO Box 7015, SE-750 07 Uppsala, Sweden.
Carbohydr Res. 2004 Apr 2;339(5):929-36. doi: 10.1016/j.carres.2003.11.008.
Bioinformatics has played a pivotal role in advancing genetics and protein sciences. The large amount of information generated by genomics, and now proteomics, has been a driving force. By comparison, glycobiology still generates small amounts of data. The need to organize our knowledge about carbohydrates is however growing constantly and has given rise to an increasing number of public databases and freely available tools. This review gives an overview of the carbohydrate-oriented resources currently available on the Internet. Many of the resources are seldom referred to in the literature and difficult to find, in part because of the constant flux of the net itself, but also because many efforts have been lead by a single individual. As the World Wide Web has matured the number of 'permanent' resources, maintained by organizations rather than individuals, has increased. In this paper, we present some of the more useful and accessible public tools and databases. There are also a few commercial initiatives but these have not been reviewed.
生物信息学在推动遗传学和蛋白质科学发展方面发挥了关键作用。基因组学以及现在的蛋白质组学所产生的大量信息一直是驱动力。相比之下,糖生物学仍然产生少量数据。然而,整理我们关于碳水化合物的知识的需求在不断增长,这催生了越来越多的公共数据库和免费可用工具。本综述概述了目前互联网上可用的面向碳水化合物的资源。许多资源在文献中很少被提及且难以找到,部分原因是网络本身的不断变化,也因为许多工作是由个人主导的。随着万维网的成熟,由组织而非个人维护的“永久性”资源数量有所增加。在本文中,我们介绍了一些更有用且易于访问的公共工具和数据库。也有一些商业举措,但未对其进行综述。