细胞色素P450/烟酰胺腺嘌呤二核苷酸磷酸依赖的反式花生四烯酸形成反式环氧化物。
Cytochrome P450/NADPH-dependent formation of trans epoxides from trans-arachidonic acids.
作者信息
Roy Uzzal, Loreau Olivier, Balazy Michael
机构信息
Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA.
出版信息
Bioorg Med Chem Lett. 2004 Feb 23;14(4):1019-22. doi: 10.1016/j.bmcl.2003.11.054.
Trans-arachidonic acids (trans-AA) are products of cis-trans isomerization of arachidonic acid by nitrogen dioxide radical (NO(2)), and occur in vivo, but their metabolism is unknown. We found that hepatic microsomes oxidized trans-AA via cytochrome P450/NADPH system to epoxides, which were hydrolyzed by epoxide hydrolase to diols (DiHETEs). 14,15-trans-AA produced one erythro diol and three threo diols each having one trans double bond.
反式花生四烯酸（trans-AA）是二氧化氮自由基（NO₂）使花生四烯酸发生顺反异构化的产物，存在于体内，但其代谢情况尚不清楚。我们发现肝微粒体通过细胞色素P450/还原型辅酶Ⅱ系统将反式花生四烯酸氧化为环氧化物，环氧化物再被环氧化物水解酶水解为二醇（DiHETEs）。14,15-反式花生四烯酸产生一种赤藓醇二醇和三种苏阿糖二醇，每种都含有一个反式双键。
Zotero 插件