抗抑郁药物的神经营养作用。

Neurotrophic effects of antidepressant drugs.

作者信息

Castrén Eero

机构信息

Sigrid Jusélius-professor of Neuroscience, Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland.

出版信息

Curr Opin Pharmacol. 2004 Feb;4(1):58-64. doi: 10.1016/j.coph.2003.10.004.

DOI:10.1016/j.coph.2003.10.004

PMID:15018840

Abstract

The past decade has witnessed a growing interest in the trophic effects of antidepressant drugs. Antidepressants stimulate the production and signaling of plasticity-related proteins such as neurotrophins and cAMP response element binding protein, and neurotrophin signaling appears to be both sufficient and necessary for antidepressant action in rodents. Furthermore, several different antidepressant treatments increase neurogenesis in rodent hippocampus and this effect correlates with the behavioral effects produced by these drugs. These data suggest that antidepressants facilitate activity-dependent selection of functional synaptic connections in brain and, through their neurotrophic effects, improve information processing within neuronal networks compromised in mood disorders.

摘要

在过去十年中，人们对抗抑郁药物的营养作用的兴趣与日俱增。抗抑郁药刺激与可塑性相关的蛋白质（如神经营养因子和环磷腺苷反应元件结合蛋白）的产生和信号传导，并且神经营养因子信号传导似乎对于啮齿动物的抗抑郁作用而言既是充分的也是必要的。此外，几种不同的抗抑郁治疗可增加啮齿动物海马体中的神经发生，并且这种效应与这些药物产生的行为效应相关。这些数据表明，抗抑郁药促进大脑中依赖活动的功能性突触连接的选择，并通过其神经营养作用，改善情绪障碍中受损的神经网络内的信息处理。