Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists.

作者信息

Sato Nagaaki, Shibata Takunobu, Jitsuoka Makoto, Ohno Toshiyuki, Takahashi Toshiyuki, Hirohashi Tomoko, Kanno Tetsuya, Iwaasa Hisashi, Kanatani Akio, Fukami Takehiro

机构信息

Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300-2611, Japan.

出版信息

Bioorg Med Chem Lett. 2004 Apr 5;14(7):1761-4. doi: 10.1016/j.bmcl.2004.01.049.

DOI:10.1016/j.bmcl.2004.01.049

PMID:15026066

Abstract

A series of substituted 4-alkoxy-2-aminopyridines 2, which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure-activity relationships and identification of potent 4-alkoxy derivatives are described.

摘要