Molderings Gerhard J, Heinen Anja, Menzel Sigrid, Lübbecke Friedrich, Homann Jürgen, Göthert Manfred
Institute of Pharmacology and Toxicology, University of Bonn, Bonn, Germany.
Ann N Y Acad Sci. 2003 Dec;1009:44-51. doi: 10.1196/annals.1304.005.
The authors report on (1) the absorption of agmatine from the gastrointestinal tract as an important source of this polycation in the organism, (2) its organ distribution, and (3) its putative role in liver regeneration. When rats received 0.5 microCi [(14)C]agmatine contained in 5 grams of standard rat chow after a fasting period of 24 hours, radioactivity was recovered in all organs investigated, in blood, and in urine. In the liver 67% +/- 7% of administered radioactivity was found. After partial (two-thirds) hepatectomy, administration of 250 mg and 500 mg agmatine by gavage for 6 days reduced liver regeneration at day 7 by 20% and 22%, respectively, compared with animals that received no agmatine. Agmatine is absorbed from the gastrointestinal tract, probably by means of a specific transporter. It is likely that agmatine in the chyme of the gut represents an essential source of agmatine in the tissues of the organism. An increase in the availability of gastrointestinal agmatine for absorption impairs liver regeneration and may contribute to the development of liver diseases.
(1) 胍丁胺从胃肠道的吸收情况，其作为生物体内这种聚阳离子的重要来源；(2) 其在各器官中的分布；(3) 其在肝脏再生中的假定作用。在禁食24小时后，当大鼠摄入含0.5微居里[(14)C]胍丁胺的5克标准大鼠饲料时，在所有研究的器官、血液和尿液中均检测到放射性。在肝脏中发现了67%±7%的给药放射性。在部分（三分之二）肝切除术后，与未接受胍丁胺的动物相比，通过灌胃给予250毫克和500毫克胍丁胺6天，第7天时肝脏再生分别减少了20%和22%。胍丁胺可能通过一种特定的转运体从胃肠道吸收。肠道食糜中的胍丁胺很可能是生物体内组织中胍丁胺的重要来源。胃肠道中可吸收的胍丁胺可用性增加会损害肝脏再生，并可能导致肝脏疾病的发展。
