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不锈钢和形状记忆合金冠状动脉支架:与血管壁相互作用的计算研究

Stainless and shape memory alloy coronary stents: a computational study on the interaction with the vascular wall.

作者信息

Migliavacca Francesco, Petrini Lorenza, Massarotti Paolo, Schievano Silvia, Auricchio Ferdinando, Dubini Gabriele

机构信息

Dipartimento di Bioingegneria, Politecnico di Milano, Milan, Italy.

出版信息

Biomech Model Mechanobiol. 2004 Jun;2(4):205-17. doi: 10.1007/s10237-004-0039-6. Epub 2004 Mar 17.

Abstract

Balloon-expandable and self-expandable stents are the two types of coronary stents available. Basically, they differ in the modality of expansion. The present study analyses the stress state induced on the vascular wall, by the expansion of balloon- and self-expandable stents, using the finite element method. Indeed, modified mechanical stress state is in part responsible in the restenosis process. The balloon-expandable stents herein investigated are assumed to be made of stainless steel, while the self-expandable stents are made of a shape memory alloy. The effects of the severity of the coronary stenosis, the atherosclerotic plaque stiffness and the stent design are investigated. Comparing the self-expandable stent with the balloon-expandable one, the former induces fewer stresses and lower damage to the vessel, but, on the other hand, its lower stiffness induces a lower capability to restore vasal lumen and to contrast arterial elastic recoil.

摘要

球囊扩张式支架和自膨胀式支架是现有的两种冠状动脉支架。基本上,它们在扩张方式上有所不同。本研究使用有限元方法分析球囊扩张式支架和自膨胀式支架扩张时在血管壁上产生的应力状态。实际上,改变的机械应力状态在再狭窄过程中部分起作用。本文研究的球囊扩张式支架假定由不锈钢制成,而自膨胀式支架由形状记忆合金制成。研究了冠状动脉狭窄严重程度、动脉粥样硬化斑块硬度和支架设计的影响。将自膨胀式支架与球囊扩张式支架进行比较,前者产生的应力较小,对血管的损伤也较小,但另一方面,其较低的硬度导致恢复血管腔和对抗动脉弹性回缩的能力较低。

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