Boccardi M, Sabattoli F, Testa C, Beltramello A, Soininen H, Frisoni G B
Laboratory of Epidemiology and Neuroimaging (L.E.N.I.), IRCCS San Giovanni di Dio - FBF, Brescia 25125, Italy.
Neurosci Lett. 2004 Feb 19;356(3):167-70. doi: 10.1016/j.neulet.2003.11.042.
To investigate the difference in the morphologic expression of frontotemporal dementia (FTD) and Alzheimer's disease (AD) in patients carrying and not carrying the epsilon4 allele of APOE, MR images of 26 controls, 18 AD patients (11 carrying the epsilon4 allele, seven non-carriers), and eight FTD (two carriers, six non-carriers) were compared using voxel by voxel analysis. Greater atrophy was found in the disease-specific regions of the epsilon4 carriers vs the non-carriers at P < 0.05 corrected: medial temporal atrophy was greater in the AD carrying the epsilon4 allele, right ventral striatal atrophy in the FTD carrying the allele. The non-carriers did not have atrophic regions compared to the carriers. The epsilon4 allele of the APOE might modulate the expression of degenerative dementias by enhancing the specific effects of neurodegenerative diseases on the brain.
为了研究携带和不携带载脂蛋白E（APOE）ε4等位基因的额颞叶痴呆（FTD）和阿尔茨海默病（AD）患者在形态学表现上的差异，使用逐像素分析比较了26名对照者、18名AD患者（11名携带ε4等位基因，7名不携带者）和8名FTD患者（2名携带者，6名不携带者）的磁共振成像（MR）图像。在经校正P<0.05时，发现ε4携带者疾病特异性区域的萎缩比非携带者更严重：携带ε4等位基因的AD患者内侧颞叶萎缩更明显，携带该等位基因的FTD患者右侧腹侧纹状体萎缩更明显。与携带者相比，非携带者没有萎缩区域。APOE的ε4等位基因可能通过增强神经退行性疾病对大脑的特定影响来调节退行性痴呆的表现。
