Ball W S, Parker J R, Davis P C, Glasier C M, Morris M R
Department of Radiology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-2899.
Invest Radiol. 1992 Aug;27 Suppl 1:S45-52.
This study assesses the efficacy of gadoteridol for contrast-enhanced magnetic resonance imaging (MRI) in children.
Patients were examined by MRI before and after receiving 0.10 mmol/kg gadoteridol. Blinded and unblinded readers analyzed brain and spine MRI studies from a multicenter clinical trial involving 101 patients at 11 sites. Ninety-two cases (76 brain, 16 spine) were evaluated by unblinded investigators, and 91 cases (76 brain, 15 spine) were evaluated by three neuroradiologists unaffiliated with any investigational site and blinded to clinical information.
Unblinded readers noted enhancement of brain pathology in 70% of cases versus 50% to 67% among blinded readers. Unblinded readers determined that additional diagnostic information was available after contrast in 82% of brain studies (average, 64% for blinded readers) and would have changed patient diagnoses in 48% of these studies (average, 46% for blinded readers). In spine cases, enhancement of pathology was noted in 38% (unblinded) and 33% to 40% (blinded). Additional diagnostic information was available after contrast in 63% of spine studies (unblinded), or an average of 58% (blinded), and patient diagnoses would have changed in 20% (unblinded), or an average of 59% (blinded).
Gadoteridol is suitable for enhanced MRI detection, localization, and characterization of central nervous system pathology in children.
本研究评估钆特醇用于儿童对比增强磁共振成像（MRI）的疗效。
患者在接受0.10 mmol/kg钆特醇前后接受MRI检查。盲法和非盲法阅片者分析了一项多中心临床试验中11个地点101例患者的脑和脊柱MRI研究。92例（76例脑部，16例脊柱）由非盲法研究者评估，91例（76例脑部，15例脊柱）由3名与任何研究地点无关且对临床信息不知情的神经放射科医生评估。
非盲法阅片者发现70%的病例脑部病变有强化，而盲法阅片者中这一比例为50%至67%。非盲法阅片者确定，82%的脑部研究在注射造影剂后可获得额外诊断信息（盲法阅片者平均为64%），其中48%的研究（盲法阅片者平均为46%）患者诊断会改变。在脊柱病例中，38%（非盲法）和33%至40%（盲法）的病变有强化。63%（非盲法）的脊柱研究在注射造影剂后可获得额外诊断信息，平均为58%（盲法），20%（非盲法）的患者诊断会改变，平均为59%（盲法）。
钆特醇适用于儿童中枢神经系统病变的增强MRI检测、定位和特征描述。
