Liao Z, Klein E, Poh C K, Huang Z, Hardy P A, Morti S, Clark W R, Gao D
Department of Mechanical Engineering, Center for Biomedical Engineering, University of Kentucky, Lexington, KY 40506, USA.
Int J Artif Organs. 2004 Feb;27(2):110-7. doi: 10.1177/039139880402700206.
Experimental approaches to optimize hollow fiber hemodialyzer design are expensive and time-consuming. Computer modeling is an effective way to study mass transfer in the hemodialyzer because a substantial reduction in experimental time and cost can be achieved. This paper presents a two-dimensional modified "equivalent annulus" model, which employs Navier-Stokes (N-S) equations to describe blood and dialysate flow, and Kedem-Katchalsky (K-K) equations to calculate transmembrane flow. N-S equations and K-K equations must be coupled together in the process of computing. The corresponding experiments were designed to validate this model, and experimental results agreed well with numerical results. The distribution of velocity, pressure and solute concentration were investigated in detail, presenting a clear insight into dialyzer mass transfer. This model can be applied to help optimize hemodialyzer design.
