Matsuoka Nobuhiro, Fukuda Isao, Kira Marimo, Uchihashi Yoshitaka, Satou Tetuso
Department of Anesthesiology, National Defense Medical College, Tokorozawa 359-8513.
Masui. 2004 Mar;53(3):277-9.
It is reported that ropivacaine, a new amide-linked local anesthetic, can be used safely in patients susceptible to malignant hyperthermia. We report a case of the use of epidural ropivacaine for a gravida with disposition for malignant hyperthermia. A 33-year-old female patient, 11 weeks and 2 days pregnant, was admitted for torsion of the right ovarian cyst. Five years before, she had been prepared for operation for uterine myoma. After premedication with atropine 0.5 mg and hydroxyzine 50 mg i.m. her body temperature increased to 39.0 degrees C, and the operation was postponed. By muscle biopsy she was diagnosed susceptible to malignant hyperthermia. Two months thereafter, the operation for uterine myoma was performed under epidural lidocaine and intravenous propofol anesthesia. Three years ago, she had cesarean section under epidural anesthesia using mepivacaine. This time, the epidural catheter was inserted at L 3-4 interspace, and 10 ml of 1.0% ropivacaine was administrated. After fifteen minutes analgesia was obtained to T 10-L 2. Forty minutes later the operation was performed and the patient was safely anesthetized by ropivacaine. Later at 37 weeks and 3 days pregnancy, cesarean section was performed with epidural ropivacaine.
据报道,新型酰胺类局部麻醉药罗哌卡因可安全用于易患恶性高热的患者。我们报告一例将硬膜外罗哌卡因用于有恶性高热倾向孕妇的病例。一名33岁女性患者,孕11周零2天,因右侧卵巢囊肿扭转入院。五年前,她曾因子宫肌瘤准备手术。在肌肉注射0.5mg阿托品和50mg羟嗪进行术前用药后,她的体温升至39.0℃,手术推迟。经肌肉活检,她被诊断为易患恶性高热。此后两个月,子宫肌瘤手术在硬膜外利多卡因和静脉丙泊酚麻醉下进行。三年前,她在硬膜外麻醉下使用甲哌卡因进行了剖宫产。此次,硬膜外导管于L3-4间隙置入,给予10ml 1.0%罗哌卡因。15分钟后镇痛平面达T10-L2。40分钟后进行手术,患者被罗哌卡因安全麻醉。后来在孕37周零3天时,再次使用硬膜外罗哌卡因进行了剖宫产。