BALB/c小鼠生殖道的实验性人型支原体感染

Experimental Mycoplasma hominis infection of the genital tract in BALB/c mice.

作者信息

Shkarupeta M M, Lazarev V N, Govorun V M

机构信息

Institute of Physicochemical Medicine, Russian Ministry of Health, Moscow.

出版信息

Bull Exp Biol Med. 2004 Jan;137(1):53-5. doi: 10.1023/b:bebm.0000024386.33789.0f.

DOI:10.1023/b:bebm.0000024386.33789.0f

PMID:15085246

Abstract

We studied the ability of laboratory and clinical strains of Mycoplasma hominis to colonize the genital tract mucosa in BALB/c mice. Colonization with mycoplasma occurred only in mice receiving estrogen. Mycoplasma hominis strains obtained after 3-fold passage through the vaginal mucosa in mice and administered intravaginally in a dose of 0.5 x 10(8) CFU/ml caused infection in 100% animals. Inflammation in the lower genital tract was reduced by the 8th week after infection.

摘要

我们研究了人型支原体的实验室菌株和临床菌株在BALB/c小鼠生殖道黏膜定殖的能力。支原体定殖仅发生在接受雌激素的小鼠中。人型支原体菌株在小鼠阴道黏膜中传代3次后获得，并以0.5×10⁸CFU/ml的剂量经阴道给药，导致100%的动物感染。感染后第8周，下生殖道的炎症减轻。