HELLP综合征、多因素血栓形成倾向与产后心肌梗死。
HELLP syndrome, multifactorial thrombophilia and postpartum myocardial infarction.
作者信息
Brandenburg Vincent M, Frank Rolf D, Heintz Bernhard, Rath Werner, Bartz Clemens
机构信息
Department of Nephrology and Clinical Immunology, University Hospital, RWTH Aachen, Aachen, Germany.
出版信息
J Perinat Med. 2004;32(2):181-3. doi: 10.1515/JPM.2004.033.
A case of postpartum acute myocardial infarction with intraventricular thrombus occurred in a woman with HELLP syndrome. Since coronary artery disease was ruled out angiographically, the assumed pathophysiological mechanism for myocardial malperfusion was intermittend coronary vasospasm and thrombosis. There were several thrombophilic risk factors detectable (heterozygous factor V Leiden, low levels of antithrombin III, protein S deficiency), whose possible impact in this rare but severe clinical condition is discussed.
一名患有HELLP综合征的女性发生了产后急性心肌梗死并伴有心室内血栓形成。由于血管造影排除了冠状动脉疾病，因此推测心肌灌注不良的病理生理机制为间歇性冠状动脉痉挛和血栓形成。检测到了几种血栓形成倾向危险因素（杂合子因子V莱顿突变、抗凝血酶III水平低、蛋白S缺乏），并讨论了它们在这种罕见但严重临床情况中可能产生的影响。
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