TCN2 776C>G对肾移植患者维生素B、叶酸和总同型半胱氨酸水平的影响。

Effects of TCN2 776C>G on vitamin B, folate, and total homocysteine levels in kidney transplant patients.

作者信息

Winkelmayer Wolfgang C, Skoupy Sonja, Eberle Corinna, Födinger Manuela, Sunder-Plassmann Gere

机构信息

The Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Kidney Int. 2004 May;65(5):1877-81. doi: 10.1111/j.1523-1755.2004.00592.x.

DOI:10.1111/j.1523-1755.2004.00592.x

PMID:15086930

Abstract

BACKGROUND

Controversy exists regarding the possible associations between a single nucleotide polymorphism of the transcobalamin II encoding gene (TCN2 776C>G) and plasma levels of vitamin B(12), folate, or total homocysteine.

METHODS

In a cross-sectional study of 732 kidney allograft recipients, patients were categorized by TCN2 776C>G genotype. In univariate and multivariate linear regression models that allowed the outcome variables vitamin B(12), folate, and total homocysteine plasma levels to follow a gamma distribution, we tested for possible associations of allelic variants of the TCN2 776C>G gene and these three dependent variables.

RESULTS

The allele frequency for TCN2 776C>G was 0.46. Heterozygosity or homozygosity for TCN2 776C>G was not associated with plasma levels of vitamin B(12) (776CG, P= 0.22; 776GG, P= 0.89), folate (776CG, P= 0.91; 776GG, P= 0.84), or total homocysteine (776CG, P= 0.11; 776GG, P= 0.33) even after adjustment for several possible confounders.

CONCLUSION

We conclude from this largest study on the subject thus far that there are no associations between allelic variants of TCN2 776C>G and plasma vitamin B(12), folate, or total homocysteine plasma levels in kidney transplant patients.

摘要

背景

关于转钴胺素II编码基因（TCN2 776C>G）的单核苷酸多态性与维生素B12、叶酸或总同型半胱氨酸血浆水平之间的可能关联存在争议。

方法

在一项对732名肾移植受者的横断面研究中，根据TCN2 776C>G基因型对患者进行分类。在单变量和多变量线性回归模型中，使维生素B12、叶酸和总同型半胱氨酸血浆水平等结果变量呈伽马分布，我们测试了TCN2 776C>G基因的等位基因变体与这三个因变量之间的可能关联。

结果

TCN2 776C>G的等位基因频率为0.46。即使在对几个可能的混杂因素进行调整后，TCN2 776C>G的杂合性或纯合性与维生素B12（776CG，P = 0.22；776GG，P = 0.89）、叶酸（776CG，P = 0.91；776GG，P = 0.84）或总同型半胱氨酸（776CG，P = 0.11；776GG，P = 0.33）的血浆水平均无关联。