[降钙素基因相关肽在豚鼠耳蜗中的分布]
[Distribution of calcitonin gene-related peptide in guinea pig cochlea].
作者信息
Qi Benming, Huang Xiang, Zhu Liangru, Tian Xinghua, Wang Jibao
机构信息
Department of Otolaryngology, First People's Hospital of Yunnan Province, Kunming, 650001, China.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 Jan;18(1):41-2.
OBJECTIVE
To observe the distribution of CGRP in guinea pig cochlea.
METHOD
CGRP was labeled by immunostaning technique. Distribution of CGRP immunoreactivity was observed with light microscopy.
RESULT
CGRP immunoreactivity was located in SGN, nerve fibers at osseous spiral lamina, stria vascularis, IHC, adjacent area of OHC and Deiters' cells.
CONCLUSION
CGRP distributes extensively in guinea pig cochlea. CGRP may play an important role as neurotransmitter and/or neuromodulator to hearing function by modulating HC, supporting cells, SGN and other neurons along the process of auditory nerve. It may have effect on on cochlear blood flow, too.
目的
观察降钙素基因相关肽（CGRP）在豚鼠耳蜗中的分布。
方法
采用免疫染色技术标记CGRP。用光镜观察CGRP免疫反应性的分布。
结果
CGRP免疫反应性位于螺旋神经节（SGN）、骨螺旋板神经纤维、血管纹、内毛细胞（IHC）、外毛细胞（OHC）相邻区域及Deiters细胞。
结论
CGRP在豚鼠耳蜗中广泛分布。CGRP可能作为神经递质和/或神经调质，通过调节毛细胞、支持细胞、螺旋神经节及沿听觉神经过程的其他神经元，对听力功能发挥重要作用。它可能对耳蜗血流也有影响。
Zotero 插件