Andrade J L, Haro J M, Castillo M A, de Luna J D, Vargas F
Departamento de Bioquímica, Facultad de Medicina, Granada, España.
Pharmacology. 1992;44(6):315-23. doi: 10.1159/000138936.
The administration of the antithyroid drug methimazole to rats via drinking water prevented the development of hypertension that usually accompanies subtotal nephrectomy and saline drinking (1% NaCl). In methimazole-treated rats, elevated blood pressure induced 5 weeks previously returned to normotensive levels. Pressor responsiveness to angiotensin, vasopressin and norepinephrine in unanesthetized rats was studied after prevention of hypertension in control, low-renal-mass hypertensive (LRM) and low-renal-mass methimazole-treated (LRM-M) rats, and in the reversion study in LRM and LRM-M rats. In LRM rats, responsiveness to vasoconstrictors was increased, whereas responsiveness to vasoconstriction was clearly reduced in LRM-M rats after prevention and reversion studies. These results suggest that (a) thyroid hormones are required in the early and established phases of LRM hypertension, and (b) the decreased pressor responsiveness to vasoconstrictors may play a role in the prevention and reversion of this type of hypertension following methimazole administration. However, the changes in pressor responsiveness may also be secondary to the reduction in blood pressure.
通过饮用水给大鼠施用抗甲状腺药物甲巯咪唑可预防通常伴随次全肾切除和饮用盐水（1%氯化钠）出现的高血压。在接受甲巯咪唑治疗的大鼠中，5周前升高的血压恢复到正常血压水平。在预防对照、低肾质量高血压（LRM）和低肾质量甲巯咪唑治疗（LRM-M）大鼠的高血压后，以及在LRM和LRM-M大鼠的逆转研究中，对未麻醉大鼠对血管紧张素、血管加压素和去甲肾上腺素的升压反应性进行了研究。在LRM大鼠中，对血管收缩剂的反应性增加，而在预防和逆转研究后，LRM-M大鼠对血管收缩的反应性明显降低。这些结果表明：（a）在LRM高血压的早期和确立阶段需要甲状腺激素；（b）对血管收缩剂升压反应性的降低可能在甲巯咪唑给药后预防和逆转此类高血压中起作用。然而，升压反应性的变化也可能继发于血压降低。
