锂治疗双相情感障碍患者可增加肌醇单磷酸酶活性。

Increased inositol-monophosphatase activity by lithium treatment in bipolar patients.

作者信息

Kaya Nezaket, Resmi Halil, Ozerdem Aysegul, Guner Gul, Tunca Zeliha

机构信息

Department of Psychiatry, School of Medicine, Dokuz Eylul University, Balcova, 35340 Izmir, Turkey.

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 2004 May;28(3):521-7. doi: 10.1016/j.pnpbp.2004.01.020.

DOI:10.1016/j.pnpbp.2004.01.020

PMID:15093960

Abstract

Inhibition of inositol monophosphatase (IMPase) enzyme is the target mechanism of action of lithium. However, increased activity of mRNA levels by lithium has been reported. These two diverse effects were shown after relatively short periods of lithium administration. The aim of this study was to observe the effect of prolonged use of lithium on IMPase activity. The authors investigated IMPase activities in fresh erythrocytes and leukocytes in 63 bipolar patients (42 euthymic, 8 depressive, 13 manic episodes) and 16 control subjects. We found that erythrocyte IMPase activity was higher in lithium treated euthymic patients than non-lithium treated patients. The duration of lithium use was positively correlated with leukocyte IMPase activity. Increased IMPase activity by chronic lithium use suggests an up-regulation of the enzyme activity.

摘要

抑制肌醇单磷酸酶（IMPase）是锂的作用靶点机制。然而，有报道称锂可使mRNA水平的活性增加。这两种不同的效应在相对较短时间的锂给药后就已显现。本研究的目的是观察长期使用锂对IMPase活性的影响。作者调查了63例双相情感障碍患者（42例心境正常、8例抑郁发作、13例躁狂发作）和16例对照受试者新鲜红细胞和白细胞中的IMPase活性。我们发现，接受锂治疗的心境正常患者的红细胞IMPase活性高于未接受锂治疗的患者。锂的使用时长与白细胞IMPase活性呈正相关。长期使用锂导致IMPase活性增加表明该酶活性上调。