CCL3-L1基因与HIV-1易感性及疾病进展相关性分析。

Analysis of the CCL3-L1 gene for association with HIV-1 susceptibility and disease progression.

作者信息

Bugeja Matthew J, Booth David R, Bennetts Bruce H, Guerin Jan, Kaldor John M, Stewart Graeme J

机构信息

Institute for Immunology and Allergy Research, Westmead Millennium Institute, Westmead Hospital, Sydney, NSW, Australia.

出版信息

AIDS. 2004 Apr 30;18(7):1069-71. doi: 10.1097/00002030-200404300-00017.

DOI:10.1097/00002030-200404300-00017

PMID:15096812

Abstract

CCL-L1 binds more potently to CCR5 than any other chemokine; it inhibits HIV-1 infection in vitro, and its gene occurs in variable copy numbers, some individuals failing to produce it. We analysed the frequency of the absence of CCL3-L1 in 268 Caucasian Australian HIV-1 patients and 260 uninfected individuals. A CCL-L1-negative genotype frequency of 2.3% was found in HIV-1 negative individuals. No association was found between the absence of CCL3-L1 and susceptibility to, or rate of progression of, HIV-1 infection.

摘要

CCL-L1与CCR5的结合比任何其他趋化因子都更有效；它在体外抑制HIV-1感染，其基因以可变拷贝数存在，一些个体无法产生它。我们分析了268名澳大利亚白种人HIV-1患者和260名未感染个体中CCL3-L1缺失的频率。在HIV-1阴性个体中发现CCL-L1阴性基因型频率为2.3%。未发现CCL3-L1缺失与HIV-1感染的易感性或进展速率之间存在关联。