Krenzelok E P, Drake T, Dean B S
Pittsburgh Poison Center, Children's Hospital of Pittsburgh, PA.
Vet Hum Toxicol. 1992 Apr;34(2):168-9.
Animal poisonings account for a significant number of the cases responded to by poison centers. The majority of consultations involve small animals and do not necessitate the use of large amounts of pharmacologic antagonists, such as atropine to treat anticholinesterase pesticide poisonings. However, large animals such as cattle present unique management problems, since phenomenal amounts of antidotes may be needed to treat a herd of cattle, creating a significant economic impact. The most challenging dilemma is providing 24-h availability and a means of acquisition of sufficient quantities of antidotes to reduce the economic impact of large-animal poisonings. In conjunction with a state veterinary medical association, a RPIC serves as a depot for the storage and distribution of emergency veterinary antidotes. Sufficient quantities of atropine, methylene blue, calcium EDTA, sodium nitrite and thiosulfate, and activated charcoal are available via the RPIC to treat a herd of 200 cattle. The antidotes are available only for emergency treatment and with a veterinary prescription. The 24-h nature of the poison center makes it an ideal location to serve the needs of veterinarians.
动物中毒病例在毒物控制中心所处理的案例中占相当大的比例。大多数咨询涉及小动物,且不一定需要使用大量的药理学拮抗剂,如用于治疗抗胆碱酯酶农药中毒的阿托品。然而,像牛这样的大型动物带来了独特的管理问题,因为治疗一群牛可能需要大量的解毒剂,这会产生重大的经济影响。最具挑战性的难题是确保24小时随时可用,并提供获取足够数量解毒剂的途径,以减少大型动物中毒造成的经济影响。与州兽医协会合作,区域毒物信息中心充当紧急兽医解毒剂的储存和分发仓库。通过区域毒物信息中心可获得足够数量的阿托品、亚甲蓝、依地酸钙钠、亚硝酸钠和硫代硫酸钠以及活性炭,用于治疗200头牛的牛群。这些解毒剂仅用于紧急治疗且需有兽医处方。毒物控制中心的24小时服务性质使其成为满足兽医需求的理想场所。