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马里巴韦和选定的吲哚咔唑对爱泼斯坦-巴尔病毒蛋白激酶BGLF4及病毒裂解复制的影响。

Effects of maribavir and selected indolocarbazoles on Epstein-Barr virus protein kinase BGLF4 and on viral lytic replication.

作者信息

Gershburg Edward, Hong Ke, Pagano Joseph S

机构信息

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

出版信息

Antimicrob Agents Chemother. 2004 May;48(5):1900-3. doi: 10.1128/AAC.48.5.1900-1903.2004.

Abstract

The human cytomegalovirus (HCMV) homolog of the Epstein-Barr virus (EBV) protein kinase (PK), UL97, is inhibited by maribavir (1263W94) and selected indolocarbazoles. Here we show that only one of these indolocarbazoles (K252a), but not maribavir, inhibits autophosphorylation of the EBV PK, BGLF4. However, maribavir and another indolocarbazole, NGIC-I, do inhibit EBV DNA synthesis, suggesting that although these last compounds inhibit both HCMV and EBV, they seem to operate through differ-ent pathways.

摘要

人巨细胞病毒(HCMV)的爱泼斯坦-巴尔病毒(EBV)蛋白激酶(PK)同源物UL97,受到马立巴韦(1263W94)和某些吲哚咔唑的抑制。在此我们表明,这些吲哚咔唑中只有一种(K252a),而非马立巴韦,可抑制EBV PK BGLF4的自身磷酸化。然而,马立巴韦和另一种吲哚咔唑NGIC-I确实能抑制EBV DNA合成,这表明尽管这些化合物对HCMV和EBV都有抑制作用,但它们似乎是通过不同途径发挥作用的。

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