不对称二甲基精氨酸：二甲基精氨酸二甲胺水解酶途径的心血管生物学
Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway.
作者信息
Vallance Patrick, Leiper James
机构信息
BHF Laboratories, Division of Medicine, University College London, Rayne Institute, 5 University St, London WC1 6JJ, UK.
出版信息
Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1023-30. doi: 10.1161/01.ATV.0000128897.54893.26. Epub 2004 Apr 22.
Abstract
An increasing number of reports indicate that endogenously produced inhibitors of nitric oxide synthase, particularly asymmetric dimethylarginine (ADMA), regulate nitric oxide generation in disease states. This article describes the biology of ADMA and the implications for cardiovascular physiology and pathophysiology.
摘要
越来越多的报告表明，内源性产生的一氧化氮合酶抑制剂，尤其是不对称二甲基精氨酸（ADMA），在疾病状态下调节一氧化氮的生成。本文描述了ADMA的生物学特性及其对心血管生理和病理生理的影响。
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