Phillips Katharine A
Department of Psychiatry, Brown University School of Medicine, Providence, Rhode Island, USA.
CNS Spectr. 2002 Jun;7(6):453-60, 463. doi: 10.1017/s109285290001796x.
Research on effective pharmacotherapy for body dysmorphic disorder (BDD) has rapidly increased in recent years, with emerging data consistently indicating that serotonin reuptake inhibitors (SRIs) are often efficacious for this disorder. Although data are limited, it appears that higher SRI doses and longer treatment trials than those used for many other psychiatric disorders are often needed to treat BDD effectively. Approaches to treatment-resistant BDD have received little investigation, but available data indicate that switching to another SRI and several SRI-augmentation strategies may be helpful. This article reviews the empirical literature on BDD and offers a recommended approach to the pharmacotherapy of this distressing and often disabling disorder.
近年来,针对躯体变形障碍(BDD)有效药物治疗的研究迅速增加,新出现的数据一致表明,5-羟色胺再摄取抑制剂(SRIs)通常对这种疾病有效。尽管数据有限,但似乎往往需要比治疗许多其他精神疾病更高的SRIs剂量和更长的治疗试验时间才能有效治疗BDD。对于难治性BDD的治疗方法研究较少,但现有数据表明,换用另一种SRIs以及几种SRIs增效策略可能会有帮助。本文回顾了关于BDD的实证文献,并针对这种令人痛苦且往往致残的疾病的药物治疗提出了推荐方法。