大环紫杉烷类似物的合成与生物活性

Synthesis and biological activity of macrocyclic taxane analogues.

作者信息

Tarrant James G, Cook Donald, Fairchild Craig, Kadow John F, Long Byron H, Rose William C, Vyas Dolatrai

机构信息

Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5100, Wallingford, CT 06492-7660, USA.

出版信息

Bioorg Med Chem Lett. 2004 May 17;14(10):2555-8. doi: 10.1016/j.bmcl.2004.02.086.

DOI:10.1016/j.bmcl.2004.02.086

PMID:15109650

Abstract

A series of paclitaxel analogues possessing a macrocyclic structure between the 7 and 10 positions has been prepared. These compounds possess in vitro activity against a paclitaxel resistant cell line and have in vivo activity comparable to paclitaxel.

摘要

已经制备了一系列在7位和10位之间具有大环结构的紫杉醇类似物。这些化合物对紫杉醇耐药细胞系具有体外活性，并且在体内具有与紫杉醇相当的活性。