Tai Amy L S, Yan Wen-Sheng, Fang Yan, Xie Dan, Sham Jonathan S T, Guan Xin-Yuan
Department of Clinical Oncology, the University of Hong Kong, Pokfulam, Hong Kong, China.
Cancer. 2004 May 1;100(9):1918-27. doi: 10.1002/cncr.20190.
Lung carcinoma is a leading cause of cancer deaths worldwide. To better understand this disease, the authors studied genetic alterations in nonsmall cell lung carcinoma (NSCLC) and the association between genetic changes and clinical features.
Genetic alterations in 30 patients with adenocarcinoma (AC) and 39 patients with squamous cell carcinoma (SCC) were analyzed by comparative genomic hybridization. The genetic changes in patients with AC and SCC were compared and the associations of these changes with clinical features were studied.
A gain of 3q with a minimal amplified region at 3q25.3-qter was significantly higher in patients with SCC compared with patients with AC (72% vs. 27%; P < 0.001). A gain of 20q and loss of chromosome 9 were detected more frequently in patients with AC compared with patients with SCC (P < 0.05). Gains of 5p and 20q and loss of 5q were significantly correlated with an advanced stage of NSCLC (P < 0.05). Amplification of 1q was significantly associated with NSCLC recurrence (P = 0.04).
The results of the current study suggested that different chromosomal aberrations may contribute to the types and pathologic stages of NSCLC.
肺癌是全球癌症死亡的主要原因。为了更好地了解这种疾病，作者研究了非小细胞肺癌（NSCLC）的基因改变以及基因变化与临床特征之间的关联。
通过比较基因组杂交分析了30例腺癌（AC）患者和39例鳞状细胞癌（SCC）患者的基因改变。比较了AC和SCC患者的基因变化，并研究了这些变化与临床特征的关联。
与AC患者相比，SCC患者中3q增益且最小扩增区域位于3q25.3 - qter的情况显著更高（72%对27%；P < 0.001）。与SCC患者相比，AC患者中20q增益和9号染色体缺失的检测频率更高（P < 0.05）。5p和20q增益以及5q缺失与NSCLC晚期显著相关（P < 0.05）。1q扩增与NSCLC复发显著相关（P = 0.04）。
当前研究结果表明，不同的染色体畸变可能与NSCLC的类型和病理分期有关。
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