抗抑郁和抗癫痫治疗的共同机制：药物与设备

Shared mechanisms of antidepressant and antiepileptic treatments: drugs and devices.

作者信息

Jobe Phillip C

机构信息

Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine, PO Box 1649, Peoria, Illinois 61656-1649, USA.

出版信息

Clin EEG Neurosci. 2004 Jan;35(1):25-37. doi: 10.1177/155005940403500109.

DOI:10.1177/155005940403500109

PMID:15112461

Abstract

Many treatments for the epilepsies and affective disorder share the properties of seizure suppression and mood stabilization. Moreover, affective disorders and the epilepsies appear to share partially similar pathogenic mechanisms. A component of the shared predisposition appears to arise from noradrenergic and serotonergic deficits. Increasing evidence supports the hypothesis that noradrenergic and/or serotonergic elevation is a mechanism of therapeutic benefit shared by most antidepressants and many antiepileptic medications. Medication induced alterations in GABAergic, glutamatergic, and CRH (corticotropin releasing hormone) containing neurons may also contribute to the shared therapeutic properties of antidepressant and antiepileptic medications.

摘要

许多针对癫痫和情感障碍的治疗方法都具有抑制癫痫发作和稳定情绪的特性。此外，情感障碍和癫痫似乎部分共享相似的致病机制。共同易感性的一个组成部分似乎源于去甲肾上腺素能和5-羟色胺能缺陷。越来越多的证据支持这样的假说，即去甲肾上腺素能和/或5-羟色胺能升高是大多数抗抑郁药和许多抗癫痫药物共有的治疗获益机制。药物引起的含γ-氨基丁酸能、谷氨酸能和促肾上腺皮质激素释放激素（CRH）神经元的改变也可能有助于抗抑郁药和抗癫痫药物的共同治疗特性。