Simulation of five intracellular C2+-regulation mechanisms in response to voltage-clamp pulses.

We report the simulation of five C2+ regulation mechanisms in response to voltage-clamp pulses applied at the membrane. We obtain the currents generated and also record the C2+ concentration changes in the whole cell during and after the pulse. Our simulator includes models for the L-type voltage-dependent C2+ channels, the C2+ pump, the Na+/C2+ exchanger and a fast buffering system, along with diffusion assuming a spheric cell shape.