用第三方单倍体相合间充质干细胞治疗严重急性移植物抗宿主病
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells.
作者信息
Le Blanc Katarina, Rasmusson Ida, Sundberg Berit, Götherström Cecilia, Hassan Moustapha, Uzunel Mehmet, Ringdén Olle
机构信息
Division of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.
出版信息
Lancet. 2004 May 1;363(9419):1439-41. doi: 10.1016/S0140-6736(04)16104-7.
Adult bone-marrow-derived mesenchymal stem cells are immunosuppressive and prolong the rejection of mismatched skin grafts in animals. We transplanted haploidentical mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-versus-host disease of the gut and liver. Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.
成人骨髓间充质干细胞具有免疫抑制作用，可延长动物体内不匹配皮肤移植的排斥反应时间。我们对一名患有严重的、治疗抵抗性的肠道和肝脏IV级急性移植物抗宿主病的患者进行了单倍体间充质干细胞移植。临床反应显著。该患者现已康复，已过去1年。我们推测间充质干细胞在体内具有强大的免疫抑制作用。
Zotero 插件