重复基因增加了物种内部和物种之间的基因表达多样性。

Duplicate genes increase gene expression diversity within and between species.

作者信息

Gu Zhenglong, Rifkin Scott A, White Kevin P, Li Wen-Hsiung

机构信息

Department of Ecology & Evolution, University of Chicago, 1101 East 57th Street, Chicago, Illinois 60637, USA.

出版信息

Nat Genet. 2004 Jun;36(6):577-9. doi: 10.1038/ng1355. Epub 2004 May 2.

DOI:10.1038/ng1355

PMID:15122255

Abstract

Using microarray gene expression data from several Drosophila species and strains, we show that duplicated genes, compared with single-copy genes, significantly increase gene expression diversity during development. We show further that duplicate genes tend to cause expression divergences between Drosophila species (or strains) to evolve faster than do single-copy genes. This conclusion is also supported by data from different yeast strains.

摘要

利用来自几种果蝇物种和品系的微阵列基因表达数据，我们发现，与单拷贝基因相比，重复基因在发育过程中显著增加了基因表达的多样性。我们进一步表明，重复基因往往会使果蝇物种（或品系）之间的表达差异比单拷贝基因进化得更快。来自不同酵母菌株的数据也支持这一结论。